Obesity has become one of the leading health problems of our time. In America, which can be considered a large sample of the whole world, research shows that 30% of the population is experiencing health problems due to advanced obesity. Of course, the most important reason for obesity is that we easily say “modern life” and take a nap! However, inactivity and plenty of calorie nutrition are our preference. That is why we are facing obesity. If we reveal the cause of obesity in this way, the basis of treatment also shows itself: finding a place for physical activity in our daily life with a balanced and low-calorie diet…

Unfortunately, studies conducted especially in people with morbid obesity show that it is very difficult and insufficient to achieve long-term and effective weight loss with lifestyle changes, medication and exercise alone. In addition, bariatric surgery, which is the main treatment, provides fast, effective permanent weight loss that is not comparable to diet and drug therapy. But surgeries also contain significant risks that can lead to major surgical treatments and death as a result.

The only treatment that can be done without risking surgery has been Endoscopic Gastric Balloons until now. Although gastric balloons, which have been applied for many different types for many years, are effective in a wide range of patients, there may also be patients who have to be removed because the stomach’s reaction to the balloon is impossible to predict its tolerance, the expected weight loss cannot be achieved, or the stomach does not accept the balloon in a very short time.

When we review all these treatments at once, I actually see this after all these years of experience: this weight loss job is not easy!

Honey, don’t lower the sails into the water right now. Of course, the search for a solution by modern medicine is sure not inferior to your determination to lose weight. Do not let a day pass so that they do not come across us with brand-new inventions and less risky, easy-to-apply methods. Here’s one of them today I’ll try to tell you when my tongue turns: Stomach Botox Application

When we said Botox, I felt like the ladies immediately listened. Yes, that’s right, Botox is a very well-known aesthetic intervention method… Especially it is used very often for wrinkles around the eyes and lips, perhaps many of our readers who read this article know even from themselves.

In short, let’s briefly remind you about botox for “beginners” who do not know so much:

Botox is actually a toxin produced by some types of a soil-borne bacterium that we call Clostiridium Botulinum. Especially the “neuro-toxin” which prevents muscle contraction is an effective protein. In other words, it causes temporary paralysis in the muscles of the area where it is applied. For this reason, it is known as a drug with wide use in different fields, especially aesthetics.

In recent days, you will start to hear its name more with a completely different field of use: Obesity Treatment!

1- What is Stomach Botox?

Stomach Botox is the process of making the “botox” injections that we apply for wrinkles on the stomach wall by a completely endoscopic method for appetite control. It has been shown that a more effective weight loss is achieved compared to diet in many different studies with botox application to the stomach without surgery, with a mild sedative.

2- How Does Stomach Botox Make You Lose Weight?

When Botox is applied endoscopically to the stomach muscle with small painless needles, it both reduces the stomach’s hunger hormone secretion and slows down the emptying of the stomach, causing the nutrients taken to stay in the stomach longer, prolonging the feeling of fullness. In other words, there is a theory that suggests that two important mechanisms are used:

The Stomach Suppresses the Hunger Hormone – It produces a hormone that makes you hungry when the stomach is empty. We call this hormone Ghrelin. Or we can also call it the Hunger Hormone. Here it has been shown in different studies that the production of Hunger Hormone is reduced by injections made to the area where this hormone is produced with stomach botox.

Gastric Emptying is Slowed Down – Due to the fact that our stomach is constantly on the move, the ground nutrients quickly leave the stomach. This is the main reason that makes us able to eat more. Stomach Botox is applied especially to the parts of the stomach that contribute to the emptying, slowing down the emptying of the stomach and prolonging the feeling of fullness.

3- Stomach Botox: A Short Endoscopic Application

Gastric Botox is applied directly by endoscopy. Endoscopy is a procedure that is performed every day for thousands of patients in every hospital of our country today. Stomach Botox is a weight loss treatment applied by endoscopy in the same way in a period of 10-15 minutes. Patients are put to sleep completely under sedation and are awakened at the end of the procedure. Almost none of our patients wake up without even remembering that an endoscopy has been performed.

4- How Much Weight Do I Lose With Stomach Botox?

Gastric Botox is a treatment that we apply to your stomach and aim to slow down stomach emptying and suppress your feeling of hunger somewhat through toxin. In clinical studies and case series conducted, it is largely revealed that the patient feels the effectiveness of botox the most after the first 3-4 weeks. This means that weight loss manifests itself most noticeably after 3 weeks. Since Stomach Botox is not a surgical method, of course, very heavy weight losses are not expected to be achieved. Nevertheless, the general average of studies shows us that weight losses of up to 10-15% of body weight have been achieved. a weight loss of about 8-12 pounds is aimed at someone who is 80 pounds in the first 3 months.

5- Is Stomach Botox Permanent?

Stomach Botox is a bacterial toxin and its effectiveness in the tissue varies between 3-6 months. It is a completely reversible treatment. It does not leave permanent effectiveness and therefore damage. The weight control effect is also not very long-term. For this reason, we recommend Stomach Botox to a very wide group of patients who are afraid of surgery and are looking for help with their diet. Another useful aspect is that the Stomach Botox procedure can be repeated when its effectiveness decreases. at the end of the 6-month period, people who want and are deemed suitable can have stomach botox again.

6- How is Stomach Botox Applied?

The person who is scheduled for Stomach Botox should come with an 8-hour hunger before the procedure. Simply put, if the procedure is to be performed at 08:00 in the morning, he is fed normally the previous day. From 24:00 at night, without eating anything, you come to the hospital on an empty stomach the next morning.

The preparation of the procedure consists of the preparation of a vascular tract. The patient is put to sleep with intravenous sedatives. In such a way that the patient does not feel in any way and does not remember the procedure, it is advanced to the stomach, and if there is no obstacle to the application of Gastric Botox, Gastric Botox is performed in small doses to certain areas of the stomach with a very small needle advanced through the endocopy. Using it in combination with blue-dyed serum when making these injections serves a function that makes it easier for the endoscopist to map the stomach and distribute doses evenly to the appropriate anatomical areas. All of these procedures are completed within 10 – 15 minutes and the patient is woken up and monitored for a short time in the rest room.

7- Who is Stomach Botox Applied To?

Anyone who has a weight problem and cannot achieve adequate weight loss through their own efforts or with the help of our expert dietitian friends can have Stomach Botox. There is no weight restriction for Stomach Botox. It can be applied in overweight patients with a Body Mass Index of more than 25 kg/m2 or obesity patients with a body mass index of more than 30 kg/m2.

However, in generally accepted practice, morbid obesity and excess weight are not preferred due to the lack of a very effective method.

There is a ratio between our height and our weight called “Body Mass Index” (BMI). It is decided by looking at this ratio whether obesity exists and how to treat obesity if there is obesity.

According to the Body Mass Index values, obesity is classified as follows.

BMI <20=””kg/m2=””=””>
BMI 20-25 kg/m2 is Normal
BMI 25-30 kg/m2 Overweight (Over-weight)
BMI 30-35 kg/m2 Mild Obesity (Class l)
BMI 35-40 kg/m2 Advanced Obesity (Class ll)
BMI 40-50 kg/m2 Morbid Obesity (Class lll)
BMI > 50 kg/m2 Super Obesity (Class lV)

Regardless of the level of your obesity, the main treatment is actually changing your lifestyle, food preferences; moving to a more active daily life and establishing a diet enriched with healthier foods.

In short, Diet and Exercise form the basis of obesity treatment.

Many patients who cannot achieve successful weight loss with diets alone may also not be suitable for bariatric surgery. Especially for this patient group, Stomach Botox Treatment can be very effective and successful in achieving effective weight loss.

8- Is Stomach Botox a Risky Procedure?

We can say that stomach Botox is the most risk-free method of weight loss. It does not require long anesthesia. it can be completed easily in 10 minutes. He leaves the hospital half an hour after the procedure. Work is done immediately. It is completely recyclable.

Although complaints of bloating, indigestion, abdominal pains, etc. have been frequently reported in dozens of studies, no serious complications have been reported. Only Dr. from Abu Dhabi. Nimeri and colleagues reported that the stomach of a 46-year-old female patient had to be removed due to gastric necrosis 2 weeks after gastric botox. When this patient was examined, it was observed that there was gastric edema, gastric outlet stenosis and bleeding, probably due to too many injections.

In standard practice, a total of 20-24 injections are accepted in terms of reliability. Spreading these injections not only to the gastric outlet, but also to the fundus, where the hunger hormone is secreted, allows both preventing the administration of too much medication to a narrow area and distributing the effectiveness to the stomach as a whole. In this way, problems such as condensation in a certain area and edema, bleeding have never been seen by many teams.

The effectiveness of Gastric Botox is independent of the number and locations of injections and is definitely temporary. First of all, it becomes very important that the physician who will perform this procedure understands this very well and does not put more burden on medical treatment than he can bear. If the boundaries of this procedure, the advantages of the application and the aspects such as the fact that it can be very long-term are explained very well while the patients are also informed, then our success is much higher.

9- Should a Diet be Done After Stomach Botox?

The main treatment for obesity is diet and exercise. All of these are defined as “Lifestyle Changes”. Stomach Botox is also a method to help patients make this change, which they cannot do alone. People who have undergone Stomach Botox should definitely exercise with regular follow-ups, following a nutrition program.

Especially liquid calorie foods prevent weight loss because they pass a very comfortable stomach. All kinds of sweets, cakes, etc. containing sugar. it reduces the effect of stomach botox.

Stomach Botox makes it easier to realize the lifestyle change that needs to be made. Making this change permanent after the effect of Stomach Botox decreases during the 6-month period allows for long-term control of weight loss.

Stay with love.

General Surgery Specialist
Obesity and Diabetes Surgery Antalya MedicalPark Hospital



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President of Organ Transplant Center at MedicalPark Hospital Antalya

Turkey's world-renowned organ transplant specialist. Dr. Demirbaş has 104 international publications and 102 national publications.

Physician's Resume:

Born on August 7, 1963 in Çorum, Prof. Dr. Alper Demirbaş has been continuing his work as the President of MedicalPark Antalya Hospital Organ Transplantation Center since 2008.

Prof. who performed the first tissue incompatible kidney transplant in Turkey, the first blood type incompatible kidney transplant, the first kidney-pancreas transplant program and the first cadaveric donor and live donor liver transplant in Antalya. Dr. As of August 2016, Alper Demirbaş has performed 4900 kidney transplants, 500 liver transplants and 95 pancreas transplants.

In addition to being the chairman of 6 national congresses, he has also been an invited speaker at 12 international and 65 national scientific congresses. Dr. Alper Demirbaş was married and the father of 1 girl and 1 boy.


Eczacibasi Medical Award of 2002, Akdeniz University Service Award of 2005, Izder Medical Man of the Year Award of 2006, BÖHAK Medical Man of the Year Award of 2007, Sabah Mediterranean Newspaper Scientist of the Year Award of 2007, ANTIKAD Scientist of the Year Award of 2009, Social Ethics Association Award of 2010, Işık University Medical Man of the Year Award of 2015, VTV Antalya's Brand Value Award of 2015.


Doctor of Medicine Degree Hacettepe University Faculty of Medicine Ankara, General Surgeon Ministry of Health Turkey EKFMG (0-477-343-8), University of Miami School of Medicine Member of Multiple Organ Transplant, ASTS Multiorgan Transplant Scholarship. Lecturer at Kyoto University. Lecturer at University of Essen, Research assistant at the University of Cambridge .

Professional Members:

American Society of Transplant Surgeons, American Transplantation Society Nominated, Middle East and Southern Africa Council Transplantation Society 2007, International Liver Transplantation Association, Turkish Transplantation Association, Turkish Society of Surgery, Turkish Hepatobiliary Surgery Association.


Our website contents consist of articles approved by our Web and Medical Editorial Board with the contributions of our physicians. Our contents are prepared only for informational purposes for public benefit. Be sure to consult your doctor for diagnosis and treatment.
Medically Reviewed by Professor Doctor Alper Demirbaş
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