Reading time is 2 mins
.
.
GAMMA AMINOBUTYRIC ACID (GABA) PSYCHONEUROIMMUNOLOGY
Fibromyalgia-Chronic Pain- Stress-GABA
Nutritionally, malnutrition, lack of exercise and social contact, emotional stress, as well as the presence of environmental toxins and / or lack of sleep also lead to us being unstable as humans. The internal environment in our body always tries to be in balance. Short, severe stress stimuli that we experience often in evolution, such as hunger, thirst, heat, cold, take us out of this homeostasis and determine the mechanisms of movement that return us to homeostasis in a significant period of time. In this case, we are talking about a short-term, physiological hormetic stimulant that is healthy and very important for maintaining he alth. This keeps us flexible.
On the other hand, the stress stimuli we are exposed to in our current society, the lack of movement, the presence of new environmental toxins created by screens or the chemical industry are generally not short-term in human evolution and are usually very new. There is no doubt that in these uncertain times of a pandemic such as the current Corona outbreak, many people are under long-term stress.
1- HPA axis
Every time our brain perceives a stress stimulus, a neuroendocrinological system is activated: the hypothalamus-pituitary-adrenal axis (HPA axis). If this HPA axis is activated for a long time and homeostasis is disturbed for a long time, as in many people today, long-term cortisol production can lead to major health problems. One of the most important interventions as a health professional is to calm the HPA axis so that the body has the opportunity to restore its homeostasis.
An interesting mechanism of action for silencing the HPA axis is the neurotransmitter GABA. This is our main (inhibitory) neurotransmitter, which slows down stimuli all over our brain as soon as sufficient excitatory signals are transmitted. Overstimulating signals can damage our brain. GABA also blocks the HPA axis (Stress).
2- GABA
GABA deficiency has been associated with restlessness or anxiety, panic attacks, insomnia, headaches, addiction, depression, epilepsy, Parkinson’s and cognitive decline. Given that in addition to our neurological system, other organs also use the inhibitory neurotransmitter GABA, a GABA deficiency is also linked to high blood pressure, diabetes, liver disorders, kidney disorders and allergies.
Strategies to increase GABA production include the following. GABA’s natural food sources include broad beans, green (leaf) vegetables, tomatoes, onions, decaying chicken eggs, fresh nuts and seeds. Sufficient building materials and cofactors are required to produce endogenous GABA. GABA is synthesized from glutamic acid by the cofactor pyridoxal-5-phosphate (active vitamin B6) under the action of the enzyme glutamate decarboxylase (GAD). Supplementing GABA with a supplement is also a good way to replenish your body’s GABA quickly. Have you considered using phytotherapy to stimulate GABA? Many plants contain GABA. Some examples are Camellia Sinensis, Valeriana Officinalis, Hypericum Perforatum and Passiflora Incarnata.
In addition, all anti-inflammatory interventions for the brain are interesting. GABA production is reduced by inflammatory activity in the brain. Omega-3 fatty acids are very important for inhibiting neuro-inflammation. Omega-3 fatty acids in the brain directly inhibit the production of cortisol.
Finally, there is a strong decoupling between the gut microbiome and GABA production. Our gut microbiome produces GABA. If our intestines contain the right bacteria, it can produce GABA itself. Intestinal health is also a factor to consider whether a person has an overactive HPA axis.
We have explained the inhibitory effect of GABA on the HPA axis and the interventions that you can do to stimulate GABA. A nutritional intervention includes an intervention that inhibits neuroinflammation (omega-3), an intervention on the microbiome (including probiotics), and the use of plant extracts that contain GABA or directly support GABA.
Wishing health days.
Turkey Medicals Co-ordinator, MD
.
.
Turkey's world-renowned organ transplant specialist. Dr. Demirbaş has 104 international publications and 102 national publications.
Physician's Resume:
Born on August 7, 1963 in Çorum, Prof. Dr. Alper Demirbaş has been continuing his work as the President of MedicalPark Antalya Hospital Organ Transplantation Center since 2008.
Prof. who performed the first tissue incompatible kidney transplant in Turkey, the first blood type incompatible kidney transplant, the first kidney-pancreas transplant program and the first cadaveric donor and live donor liver transplant in Antalya. Dr. As of August 2016, Alper Demirbaş has performed 4900 kidney transplants, 500 liver transplants and 95 pancreas transplants.
In addition to being the chairman of 6 national congresses, he has also been an invited speaker at 12 international and 65 national scientific congresses. Dr. Alper Demirbaş was married and the father of 1 girl and 1 boy.
Awards:
Eczacibasi Medical Award of 2002, Akdeniz University Service Award of 2005, Izder Medical Man of the Year Award of 2006, BÖHAK Medical Man of the Year Award of 2007, Sabah Mediterranean Newspaper Scientist of the Year Award of 2007, ANTIKAD Scientist of the Year Award of 2009, Social Ethics Association Award of 2010, Işık University Medical Man of the Year Award of 2015, VTV Antalya's Brand Value Award of 2015.
Certificates:
Doctor of Medicine Degree Hacettepe University Faculty of Medicine Ankara, General Surgeon Ministry of Health Turkey EKFMG (0-477-343-8), University of Miami School of Medicine Member of Multiple Organ Transplant, ASTS Multiorgan Transplant Scholarship. Lecturer at Kyoto University. Lecturer at University of Essen, Research assistant at the University of Cambridge .
Professional Members:
American Society of Transplant Surgeons, American Transplantation Society Nominated, Middle East and Southern Africa Council Transplantation Society 2007, International Liver Transplantation Association, Turkish Transplantation Association, Turkish Society of Surgery, Turkish Hepatobiliary Surgery Association.
Disclaimer:
Our website contents consist of articles approved by our Web and Medical Editorial Board with the contributions of our physicians. Our contents are prepared only for informational purposes for public benefit. Be sure to consult your doctor for diagnosis and treatment.