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HOW DOES TURKISH ALCOHOL AFFECT THE BRAIN?
Turkey Medicals member and hospital department our Turkish Psychologist Wishes To Please, “It causes structural changes that occur in the brain in alcohol addicts and disruptions in physiological functions. Alcohol acts on cerebral blood flow and brain glucose metabolism in the synthesis and destruction of various neural transmitters.”
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IT IS POSSIBLE TO COLLECT THE EFFECT OF ALCOHOL ON THE BRAIN IN THREE GROUPS
Physiological changes
Neurochemical changes
Structural changes
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1- WHAT ARE THE PHYSIOLOGICAL CHANGES?
Inhibition of glucose utilization is greater in chronic alcoholics. It is the relationship between the distribution of decodiazepine receptors in the human brain and the inhibition of glucose utilization. In the studies conducted, it has been shown that alcohol affects the slowing of glucose metabolism in the brain, and it has also been reported that regional cerebral blood flow increases in acute alcohol intoxication. In addition, it has been observed that cerebral blood flow and oxygen utilization are reduced in chronic alcohol addicts, and one of the regions with the greatest regional decrease in cerebral blood flow is the frontal cortex. It has been established that stroke (stroke) is very common in alcohol addicts. Alcohol has an important role in strokes due to cerebral hemorrhage, especially at a young age.
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2- WHAT ARE THE NEUROCHEMICAL CHANGES?
Alcohol is a GABA (Gamma-Aminobutyric acid) receptor inhibitor. GABA is the most important inhibitory neural transporter of the central nervous system and hyperpolarization occurs by increasing the passage of chlorine into neurons. The depressing effect of alcohol is complexed with the GABA receptor. Studies conducted in chronic alcohol addicts have shown that plasma GABA levels decrease.
It was found that the plasma GABA level in the sons of alcohol-dependent fathers who were not addicted to alcohol was significantly lower than in the sons of fathers who had never used alcohol in their family. In studies with serotonergic drugs, it has been suggested that reducing alcohol intake is important for alcoholics to cover their anti-social behavior caused by a disorder in brain serotonin metabolism with alcohol, as well as other neural carriers in alcoholics, a disorder in brain serotonin metabolism. It is difficult to explain alcohol dependence with a single nervous carrier. However, it is a fact that both the synthesis and receptors are impaired in the neural carriers of alcoholics such as serotonin, noradrenaline, GABA in the CSF (cerebrospinal fluid) in the CNS (central nervous system).
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3- WHAT ARE THE STRUCTURAL CHANGES?
One of the most important structural changes caused by alcohol in the brain in those who drink alcohol for a long time is the shrinkage of the brain. in 1971, this shrinkage was detected by pneumoencephalography, and then by computed tomography (CT). The most important part of the cortex area affected by alcohol in the brain is the frontal cortex area. In brain blood flow studies, it has been observed that regional blood flow reduction is most common in the frontal and parietal cortex. Especially in young people and those who do not have a long drinking time, the phenomenon of brain shrinkage can be reversible. After the cessation of alcohol, the brain becomes normal. Both neuradiological and neuropsychological studies have shown that the brain of women is more sensitive to alcohol than men in Turkey, that is, it is more damaged.
As a result, people who drink alcohol may experience a slowdown in DNA and protein synthesis as a result of the effects of alcohol, which can cause many functional changes and cell death in the brain.
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Turkey's world-renowned organ transplant specialist. Dr. Demirbaş has 104 international publications and 102 national publications.
Physician's Resume:
Born on August 7, 1963 in Çorum, Prof. Dr. Alper Demirbaş has been continuing his work as the President of MedicalPark Antalya Hospital Organ Transplantation Center since 2008.
Prof. who performed the first tissue incompatible kidney transplant in Turkey, the first blood type incompatible kidney transplant, the first kidney-pancreas transplant program and the first cadaveric donor and live donor liver transplant in Antalya. Dr. As of August 2016, Alper Demirbaş has performed 4900 kidney transplants, 500 liver transplants and 95 pancreas transplants.
In addition to being the chairman of 6 national congresses, he has also been an invited speaker at 12 international and 65 national scientific congresses. Dr. Alper Demirbaş was married and the father of 1 girl and 1 boy.
Awards:
Eczacibasi Medical Award of 2002, Akdeniz University Service Award of 2005, Izder Medical Man of the Year Award of 2006, BÖHAK Medical Man of the Year Award of 2007, Sabah Mediterranean Newspaper Scientist of the Year Award of 2007, ANTIKAD Scientist of the Year Award of 2009, Social Ethics Association Award of 2010, Işık University Medical Man of the Year Award of 2015, VTV Antalya's Brand Value Award of 2015.
Certificates:
Doctor of Medicine Degree Hacettepe University Faculty of Medicine Ankara, General Surgeon Ministry of Health Turkey EKFMG (0-477-343-8), University of Miami School of Medicine Member of Multiple Organ Transplant, ASTS Multiorgan Transplant Scholarship. Lecturer at Kyoto University. Lecturer at University of Essen, Research assistant at the University of Cambridge .
Professional Members:
American Society of Transplant Surgeons, American Transplantation Society Nominated, Middle East and Southern Africa Council Transplantation Society 2007, International Liver Transplantation Association, Turkish Transplantation Association, Turkish Society of Surgery, Turkish Hepatobiliary Surgery Association.
Disclaimer:
Our website contents consist of articles approved by our Web and Medical Editorial Board with the contributions of our physicians. Our contents are prepared only for informational purposes for public benefit. Be sure to consult your doctor for diagnosis and treatment.