USE OF STEM CELLS IN THE TREATMENT OF DISEASES

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STEM CELL TRANSPLANTATION IN ISTANBUL TURKEY

For a long time, adult stem cell therapies have been successfully applied in some blood diseases, such as leukemia. In recent years, the main promising studies have been related to its use in the treatment of many diseases such as stroke, some eye retinal diseases and heart attacks that lead to cell death. However, serious controlled and long-term follow-up studies are needed on these issues. Although it is less studied, there are experimental studies on many topics such as skin diseases, infertility, hair loss, dental treatments. You can find some of the most studied disease groups below.

1- Stem cell and blood diseases

Hematopoietic Stem Cell Transplantation (HSCT) is a method used for the treatment of patients with severe aplastic anemia, leukemia and some other malignancies (1). The use of adult cells is not controversial, like embryo stem cells; an embryo does not have to be destroyed, because it was taken from a person, the risk of cancer is much less common problems such as tissue rejection.

2- Stem cell and stroke treatments

In recent years, the use of stem cells in the treatment of traumatic spinal cord injury (OY) has had promising results. there are various source stem cells that can be used for transplantation, such as neural stem cells (nerve root cells) or embryonic stem cells (ECD). Experimental and clinical trials are currently underway for the potential use of stem cells in the treatment of VOTING. As the possibility of treating nerve cells by transplantation develops, OY, which is usually not treated by surgical intervention, will enter the field of neurosurgery. Therefore, training of neurosurgeons in the field of stem cell biology is necessary (2).

Stroke treatment with stem cells alone is one of the most abused issues. Neurosurgery specialist from Nicosia Near East University Mr. Erkan Kaptanoglu drew particular attention to this issue in the discussion section of his study:

A few years ago, the actual repair (regeneration) of the spinal cord was considered impossible. Although a satisfactory treatment method has not yet been found today, it is fortunate that the results of cell, animal and recent human experiments and research are promising.

As a result of the Phase I studies published in limited numbers, it is stated that long-term, case-controlled, randomized, blind, multicenter studies are needed to prove the effectiveness of the treatment methods reported. Otherwise, a method that has not been clinically researched or has not yet been completed cannot be considered a standard treatment method.

Patients who are paralyzed as a result of spinal cord injury and their families have to struggle spiritually, socially, physically and financially with this severe pathology and disability. Some science centers report that stem cells are a panacea. It is possible to come across ads on the Internet and in the media stating that it heals patients for a certain fee by using these cells or similar ones. It should be taken into account that clinics that announce by advertising that they cure patients with spinal cord injury have never encountered scientific publications or scientific research on this subject. These trials, experiences or information should be shared and discussed in scientific settings with scientific, evidence-based, provable and reproducible features before being shared with patients and their families (3).

3- Stem cells and blindness

In recent years, stem cells have been the hope of treatment for some hereditary and acquired diseases of the retina that result in blindness. Experimental studies conducted over the past 10 years have shown that it is possible to replace advanced specialized cell losses in the retina by ocular and extracellular stem cell sources and maintain their function. Mesenchymal stem cells are preferred in these studies because they have fewer ethical problems and are easy to obtain (4).

4- Stem cells and heart attacks

In many studies, it has been found that transplanted stem cells provide the formation of cardiomyocytes(heart muscle cells) and new vessels, and beyond that, cardiomyocytes show a contractile function (5).

5- Islam’s view of stem cells

For our readers who are concerned about this, Marmara University Faculty of Theology Faculty Member, M. I would like to complete this by including a work by Saim Yeprem.

Since this issue cannot be found directly in the verses of the Qur’an, it is the most appropriate approach to consider it in the form of “Stem Cell Studies from the Point of View of the Basic Principles of Islam” extracted from the whole of the Qur’an. Since the beginning of man is a “zygote” state, whether it is in the laboratory or in the womb, it is impossible to look positively at the culling of an embryo in order to obtain stem cells. However, materials such as pregnancy terminated for any reason, miscarriage, abortion and increased embryos after implantation in IVF can be used for these purposes. Islam supports alternative studies, such as the use of adult stem cells instead of embryonic stem cells, stem cells obtained from miscarried or stillborn babies. This will bring less problems. But if stem cell research is used for lofty purposes, such as treating or preventing a disease, of course, this intervention should be considered an intervention also supported and recommended by Islam (6).

Wishing you health days.

Turkey Medicals Co-ordinator, MD

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Resources:

1. Gamze AKBULUT, Medical Nutrition Treatment in Hematopoietic Stem Cell Transplantation (HKHT). International Journal of Hematology and Oncology 2013, Vol 23, Num 1 Page(s): 055-065.

2. Serdar KABATAŞ, Yang D. TENG.The Potential Roles of Neural Stem Cells in the Treatment of Spinal Cord Injury: A Review of the Literature. Turksih Neurosurgery. 2010, Volume 20, Number 2, Page(s) 103-110

3. Erkan KAPTANOGLU, Department of Brain and Neurosurgery, Faculty of Medicine, Near East University, Nicosia, Cyprus

4. Gökhan ÖZGE, Güngör SOBACI, GATA Göz Hastalıkları A.D

5. Min JY, Sullivan MF, Yang Y, et al. Significant improvement of heart function by cotransplantation of human mesenchymal stem cells and fetal cardiomyocytes in postinfarcted pigs. Ann Thorac 2002; 74: 1568-75.

6. M. Saim YEPREM. Lecturer, Faculty of Theology, Marmara University, ISTANBUL. An Islamic Perspective and On Stem Cell. Turkiye Klinikleri J Surg Med Sci 2006;2(43):87-90

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President of Organ Transplant Center at MedicalPark Hospital Antalya

Turkey's world-renowned organ transplant specialist. Dr. Demirbaş has 104 international publications and 102 national publications.

Physician's Resume:

Born on August 7, 1963 in Çorum, Prof. Dr. Alper Demirbaş has been continuing his work as the President of MedicalPark Antalya Hospital Organ Transplantation Center since 2008.

Prof. who performed the first tissue incompatible kidney transplant in Turkey, the first blood type incompatible kidney transplant, the first kidney-pancreas transplant program and the first cadaveric donor and live donor liver transplant in Antalya. Dr. As of August 2016, Alper Demirbaş has performed 4900 kidney transplants, 500 liver transplants and 95 pancreas transplants.

In addition to being the chairman of 6 national congresses, he has also been an invited speaker at 12 international and 65 national scientific congresses. Dr. Alper Demirbaş was married and the father of 1 girl and 1 boy.

Awards:

Eczacibasi Medical Award of 2002, Akdeniz University Service Award of 2005, Izder Medical Man of the Year Award of 2006, BÖHAK Medical Man of the Year Award of 2007, Sabah Mediterranean Newspaper Scientist of the Year Award of 2007, ANTIKAD Scientist of the Year Award of 2009, Social Ethics Association Award of 2010, Işık University Medical Man of the Year Award of 2015, VTV Antalya's Brand Value Award of 2015.

Certificates:

Doctor of Medicine Degree Hacettepe University Faculty of Medicine Ankara, General Surgeon Ministry of Health Turkey EKFMG (0-477-343-8), University of Miami School of Medicine Member of Multiple Organ Transplant, ASTS Multiorgan Transplant Scholarship. Lecturer at Kyoto University. Lecturer at University of Essen, Research assistant at the University of Cambridge .

Professional Members:

American Society of Transplant Surgeons, American Transplantation Society Nominated, Middle East and Southern Africa Council Transplantation Society 2007, International Liver Transplantation Association, Turkish Transplantation Association, Turkish Society of Surgery, Turkish Hepatobiliary Surgery Association.

Disclaimer:

Our website contents consist of articles approved by our Web and Medical Editorial Board with the contributions of our physicians. Our contents are prepared only for informational purposes for public benefit. Be sure to consult your doctor for diagnosis and treatment.
Medically Reviewed by Professor Doctor Alper Demirbaş
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