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WHAT IS JUVENILE MYELOMONOCYTIC LEUKEMIA? CAUSES, SYMPTOMS AND TREATMENT OF JUVENILE MYELOMONOCYTIC LEUKEMIA
Juvenile myelomonocytic leukemia (JMML), what is juvenile myelomonocytic leukemia (JMML), usually seen in children under 2 years of age? All the details about the causes, symptoms and treatment of juvenile myelomonocytic leukemia can be found in our Turkey Health news.
Turkey Medicals – so, what is juvenile myelomonocytic leukemia (JMML)? Causes, symptoms and treatment of juvenile myelomonocytic leukemia.
Juvenile Myelomyocytic leukemia (JMML) is a rare type of blood cancer that occurs when white blood cells are severely disrupted by bone marrow production. What to know about the causes, symptoms and treatment of juvenile myelomonocytic leukemia in our news.
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WHAT IS JUVENILE MYELOMONOSTIC LEUKEMIA (JMML)?
Juvenile myelomonocytic leukemia (JMML) is a rare chronic and aggressive type of leukemia that affects infants and young children. World Health Organization includes JMML in a group called “myelodysplastic and myeloproliferative disorders.” The average age of diagnosis of patients is around 2 years of age and is rare in children over 5-6 years of age. Boys are more common than girls.
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CAUSES OF JUVENILE MYELOMONOSTIC LEUKEMIA (JMML)
The cause of JMML is unknown, but doctors around the world know that certain medical conditions, such as neurofibromatosis type 1 and Noonan syndrome, can increase the likelihood of a child developing it.
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SYMPTOMS OF JUVENILE MYELOMONOSTIC LEUKEMIA (JMML)
JMML can cause quite severe symptoms in children. These symptoms include:
- Fever
- Paleness
- Bleeding (skin)
- Infection
- Hepatosplenomegaly (an enlarged liver and spleen)
- Lymphadenopathy (swollen lymph nodes)
- Recurrent lung infection
- Erythematous maculopapular rash/xanthogranuloma (recurrent rash)
- Bloody gayta
- Developmental retardation
- Central nervous system involvement (rarely)
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TREATMENT OF JUVENILE MYELOMONOSTIC LEUKEMIA IN TURKEY
Currently, the only potential therapeutic option is allogeneic hematopoietic stem cell transplantation, a type of bone marrow transplant. Hematopoietic stem cells are used to treat different types of blood cells (for example, blood cells)., Red blood cells, white blood cells, platelets) are special cells found in the bone marrow that produce. In allogeneic stem cell transplantation, intensive chemotherapy is given to kill JMML cells. However, healthy blood cells are also affected, and the bone marrow is essentially erased. Affected individuals then receive stem cells from another person, usually a close family member, or an unrelated donor that contains cord blood units. The transplanted cells go to the bone marrow when they begin to produce healthy blood cells. Stem cell transplants have the potential to correct the inherited genetic defect of white blood cells of individuals with JMML. However, stem cell transplantation in Antalya Turkey can cause serious, even life-threatening complications.
Graft (donor) rejection and graft-versus-host disease, bone marrow transplant procedure, including any possible complications. About 50% of children with JMML who have undergone hematopoietic stem cell transplantation will reach long-term remission. However, in about 35-40% of cases, usually within the first year, relapses will occur. In these cases, a second stem cell transplant in Antalya and Istanbul can be performed and has proven useful in many individuals.
Some individuals with JMML have undergone surgical removal of the spleen (splenectomy) as part of the treatment plan. However, the necessity and benefit of this procedure is controversial. Some researchers believe that the spleen harbors leukemia cells, which may be a potential source for relapse. However, removal of the spleen increases the risk of infection and has shown no statistical benefit in terms of the exact likelihood of recovery from the disease. Pretransplant splenectomy is not recommended unless Turkish clinically professors indicate for symptomatic relief in high-tech Turkey university hospitals.
Additional treatment is symptomatic and supportive. For example, antibiotics may be given to help prevent or fight infections in Turkish university hospitals. . .
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