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PANCREATIC ENZYME DEFICIENCY SYMPTOMS AND TREATMENT IN TURKEY
1- Psychoneuroimmunology
The gastrointestinal system (digestive system) should always be the center of the treatment of our patients. In general, the focus is mainly on the function of the intestine and liver. These are, of course, very important parts of digestion that should always be paid attention to. But the functioning of the pancreas also plays an important and central role in digestion.
The pancreas is an organ that secretes both hormones (Endocrine) and digestive enzymes (Exocrine). Poor nutrition and eating too many meals during the day prevent the pancreas from taking care of digestive affairs. Instead, he is forced to deal mainly with blood sugar. As a result, digestive problems and other related problems arise.
The pancreas usually has to think about the production of insulin and glucagon. This especially neutralizes the function of the pancreas in the digestive tract. Our current lifestyle and diet ask a lot from the pancreas. The western diet, which definitely contains a lot of carbohydrates, puts stress on the pancreas.
2- Decrease in exocrine pancreatic function
Decreased pancreatic exocrine function is characterized by decreased activity of pancreatic enzymes in the small intestine. The causes of impaired exocrine pancreatic function are very diverse. In animal and human studies (including Dominguez-Munoz, 2007) show that the following is often caused by:
Spasm of the sphincter of Oddi
Problems in the endocrine part of the pancreas
Gallbladder stones
Alcohol abuse
Tobacco
Micronutrient deficiency
A diet with too many (refined) carbohydrates
High-calorie diet
Intake of legumes and cereals in large quantities
Too little / too much movement
The high levels of legumes and cereals in our current diet are probably one of the main causes of exocrine pancreatic insufficiency. in the 1980s and 1990s, various studies showed that cereals and protease inhibitors in legumes were able to inhibit the production and activation of pancreatic enzymes. in 1999, Loren Cordain added that fibers obtained from cereals and legumes contain lectins, saponins and protease inhibitors, which have a great effect on exocrine pancreatic function.
3- Endocrine and exocrine go together
A very important factor in exocrine pancreatic insufficiency is an overloaded endocrine function of the pancreas. Both the endocrine part and the exocrine part of the pancreas are affected by each other. Inadequate blood sugar management (including hypoglycemia and diabetes) has a major impact on the quality of the digestive system. However, this also applies to another way. Poor exocrine function also has important consequences for the endocrine function of the pancreas.
Therefore, most often the treatment will not only have to consistently support one of the two functions of the pancreas, but we will also have to implement a complete intervention. Both endocrine function and exocrine function should be treated.
4- Symptoms of exocrine pancreatic insufficiency
Most of the symptoms are caused by poor digestion of fats, proteins and carbohydrates. This is why most people who suffer from EPI almost always have oily stools. The most common symptoms are:
Digestive complaints, including diarrhea
Greasy, sticky, smelly stools
Bloating
Bad breath
Headache
Lower abdominal pain
Poor absorption of fatty acids and fat-soluble nutrients
Endocrine system exhaustion
Primary pancreatic disorders are often the result of exocrine pancreatic insufficiency:
Chronic pancreatitis
Cyst Fibrosis
Acute pancreatitis
Pancreatic cancer
Exocrine pancreatic insufficiency also plays an important role in other syndromes:
Crohn’s disease
Lactose absorption disorder
Exocrine pancreatic insufficiency is a common condition that, if left unchecked, can lead to many other health problems. EPI treatment should be with a proper diet, adequate exercise, relaxation, optimization of the intestinal flora and intestinal epithelium, and supplementation of digestive enzymes. (Please note that this is contraindicated in forms of pancreatitis). Exocrine tissue as well as endocrine tissue must be repaired!
After EPI is discovered and treated, intestinal treatment can be successfully started. The combination of adequate digestive enzymes with optimal intestinal flora is the basis for healthy digestion and, therefore, a successful treatment.
5- Result
It is not only the endocrine function of the pancreas that is important for health. In particular, the exocrine function of the pancreas plays an important role in digestion and therefore requires great attention in digestive complaints and disorders. Pancreatic exocrine function consists of producing digestive enzymes and sodium bicarbonate. Exocrine pancreatic insufficiency is common and is primarily caused by our current lifestyle, including improper nutrition, too much alcohol, stress and too little exercise. Exocrine function also affects endocrine function, or vice versa. Therefore, problems with blood sugar management cause problems in exocrine function. Good therapy provides support for both tissue types and therefore there should be a complete intervention.
The above content is for informational purposes. The necessary assessments and applications should becarried out under the supervision of a health professional.
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Turkey's world-renowned organ transplant specialist. Dr. Demirbaş has 104 international publications and 102 national publications.
Physician's Resume:
Born on August 7, 1963 in Çorum, Prof. Dr. Alper Demirbaş has been continuing his work as the President of MedicalPark Antalya Hospital Organ Transplantation Center since 2008.
Prof. who performed the first tissue incompatible kidney transplant in Turkey, the first blood type incompatible kidney transplant, the first kidney-pancreas transplant program and the first cadaveric donor and live donor liver transplant in Antalya. Dr. As of August 2016, Alper Demirbaş has performed 4900 kidney transplants, 500 liver transplants and 95 pancreas transplants.
In addition to being the chairman of 6 national congresses, he has also been an invited speaker at 12 international and 65 national scientific congresses. Dr. Alper Demirbaş was married and the father of 1 girl and 1 boy.
Awards:
Eczacibasi Medical Award of 2002, Akdeniz University Service Award of 2005, Izder Medical Man of the Year Award of 2006, BÖHAK Medical Man of the Year Award of 2007, Sabah Mediterranean Newspaper Scientist of the Year Award of 2007, ANTIKAD Scientist of the Year Award of 2009, Social Ethics Association Award of 2010, Işık University Medical Man of the Year Award of 2015, VTV Antalya's Brand Value Award of 2015.
Certificates:
Doctor of Medicine Degree Hacettepe University Faculty of Medicine Ankara, General Surgeon Ministry of Health Turkey EKFMG (0-477-343-8), University of Miami School of Medicine Member of Multiple Organ Transplant, ASTS Multiorgan Transplant Scholarship. Lecturer at Kyoto University. Lecturer at University of Essen, Research assistant at the University of Cambridge .
Professional Members:
American Society of Transplant Surgeons, American Transplantation Society Nominated, Middle East and Southern Africa Council Transplantation Society 2007, International Liver Transplantation Association, Turkish Transplantation Association, Turkish Society of Surgery, Turkish Hepatobiliary Surgery Association.
Disclaimer:
Our website contents consist of articles approved by our Web and Medical Editorial Board with the contributions of our physicians. Our contents are prepared only for informational purposes for public benefit. Be sure to consult your doctor for diagnosis and treatment.