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In gonarthrosis, various medications can be given into the knee. It is often not a painful application when done properly. Although there is no need to perform local anesthesia before the injection, we perform the numbing process with a cooling spray just before the injection to the place where we inserted the needle. A feeling of fullness and aching may occur in the joint within a few days after the injection, this condition is normal and temporary.

Substances that can be given by injection into the knee are generally Corticosteroids (cortisone) and Hyaluronic Acid, also called “cartilage protective agent”.

Hyaluronic acid injections are also divided into “low molecular weight” and “high molecular weight” among themselves. Decongestant hyaluronic acid injections are also divided into “low molecular weight” and “high molecular weight”. Due to the fact that it is effective both for a longer time and gives more effective results in the disease, the high molecular weight one has been used more widely in recent years.

In addition to these, PRP injection has also been tried for some time in the world as a treatment for arthritis, but it has lost its validity in treatment because the expected good results could not be obtained.


It helps to reduce the pain caused by calcification for a certain period of time and thus can improve the patient’s quality of life. Hyaluronic acid injection therapy is not a powerful method that will eliminate the option of prosthetic surgery, but it has an effect that can prolong the process leading to surgery. The main goal is to provide joint lubricity and increase the durability of cartilage by replacing the decreased hyaluronic acid in the joint.

In the latest studies of the American International Orthoarthritis Research Association, the importance of the role of hyaluronic acid made into the joint and at the same time protecting the articular cartilage has been emphasized. Although there is no miraculous treatment at a level that will eliminate the option of knee replacement surgery, it constitutes an important step in the treatment of arthritis.

As a matter of fact, in addition to its lubricating and shock absorbing effect on the joint, Hyaluronic Acid also works by affecting the activity of prostaglandin and cytokines, which increase inflammation in the joint.

Corticosteroids, on the other hand, have long been used in the treatment of arthritis with their pain-relieving and inflammation-reducing effects. However, their duration of action is short and they should be used in repeated doses. It is more suitable to be used for the initial stages of calcification disease.

Op. Dr.
Specialist in Adult and Pediatric Orthopedics, Pendik MedicalPark Hospital



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President of Organ Transplant Center at MedicalPark Hospital Antalya

Turkey's world-renowned organ transplant specialist. Dr. Demirbaş has 104 international publications and 102 national publications.

Physician's Resume:

Born on August 7, 1963 in Çorum, Prof. Dr. Alper Demirbaş has been continuing his work as the President of MedicalPark Antalya Hospital Organ Transplantation Center since 2008.

Prof. who performed the first tissue incompatible kidney transplant in Turkey, the first blood type incompatible kidney transplant, the first kidney-pancreas transplant program and the first cadaveric donor and live donor liver transplant in Antalya. Dr. As of August 2016, Alper Demirbaş has performed 4900 kidney transplants, 500 liver transplants and 95 pancreas transplants.

In addition to being the chairman of 6 national congresses, he has also been an invited speaker at 12 international and 65 national scientific congresses. Dr. Alper Demirbaş was married and the father of 1 girl and 1 boy.


Eczacibasi Medical Award of 2002, Akdeniz University Service Award of 2005, Izder Medical Man of the Year Award of 2006, BÖHAK Medical Man of the Year Award of 2007, Sabah Mediterranean Newspaper Scientist of the Year Award of 2007, ANTIKAD Scientist of the Year Award of 2009, Social Ethics Association Award of 2010, Işık University Medical Man of the Year Award of 2015, VTV Antalya's Brand Value Award of 2015.


Doctor of Medicine Degree Hacettepe University Faculty of Medicine Ankara, General Surgeon Ministry of Health Turkey EKFMG (0-477-343-8), University of Miami School of Medicine Member of Multiple Organ Transplant, ASTS Multiorgan Transplant Scholarship. Lecturer at Kyoto University. Lecturer at University of Essen, Research assistant at the University of Cambridge .

Professional Members:

American Society of Transplant Surgeons, American Transplantation Society Nominated, Middle East and Southern Africa Council Transplantation Society 2007, International Liver Transplantation Association, Turkish Transplantation Association, Turkish Society of Surgery, Turkish Hepatobiliary Surgery Association.


Our website contents consist of articles approved by our Web and Medical Editorial Board with the contributions of our physicians. Our contents are prepared only for informational purposes for public benefit. Be sure to consult your doctor for diagnosis and treatment.
Medically Reviewed by Professor Doctor Alper Demirbaş
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