Reading time is 3 mins
.
.
THE STOMACH GERM ALSO TARGETS THE BRAIN
Stating that Helicobacter Pylori, known as the ’stomach germ’, is associated with neurological diseases such as Parkinson’s and Alzheimer’s, Turkey Medicals member and hospital department Neurologist Professor Doctor “It does this by various mechanisms, for example, with systemic inflammation,” was said.
Helicobacter Pylori, a common problem in our country. This bacterium, which lives in the body for years without any symptoms and causes diseases such as gastritis, ulcers, stomach cancer, according to scientific research, can also lead to neurological diseases. Neurology Specialist Professor Doctor, said direct contact, can contaminate food and water, abdominal pain, nausea, loss of appetite, frequent burping, bloating, and the bacteria that leads to symptoms such as unexplained weight loss explained the effects to the brain.
It multiplies when stomach acid decreases
H. Pylori settles in the stomach with low acidity and multiplies. After reproduction, it releases ammonia as a waste product, and since ammonia will make the stomach alkaline, H. Pylori hides under the mucous layer of the stomach to protect itself from stomach acid. H. Since the ammonia released by pylori is alkaline, it can reduce the acid of the stomach, making the stomach a more hospitable home for bacteria and other microbes.
It damages the intestinal mucosa
Helicobacter Pylori can lead to neurological diseases such as Parkinson’s, Alzheimer’s and Guillain-Barre Syndrome. It does this through various mechanisms. The most important of these mechanisms is the systemic inflammation caused by it. Helicobacter Pylori damages the intestinal mucosa and causes inflammation. This damaged intestinal mucosa initiates a cytokine reaction as an immune response, allowing the passage of larger, incorrectly digested protein particles into the circulation. Cytokines that participate in the circulation can cause inflammation of the brain and the death of neurons. Helicobacter Pylori infection usually lasts a lifetime and makes the inflammatory response chronic.
It interferes with the absorption of vitamins B6, B9 and B12
Other mechanisms of Helicobacter Pylori causing neurological disorders are to cause impaired absorption of vitamin B6, B12 and folate (B9) and to increase homocysteine levels. In order for B vitamins to be absorbed, they must be exposed to high stomach acid. But H. Pylori leads to a decrease in stomach acid, preventing the absorption of vitamins B6, B9 folate and B12. Because of this, reduced amounts of B12 and folate in the body cannot convert homocysteine, and there is an accumulation of homocysteine in the body. Homocysteine is toxic to endothelial cells and is a very important risk factor for vascular diseases. It can cause many diseases, from dementia to heart and vascular diseases.
.
HERE ARE THE NEUROLOGICAL DISEASES CAUSED BY
Parkinson:
The disease occurs with the loss of dopamine nerve cells. Cytokines in the bloodstream cause disruption of the blood-brain barrier and make the brain vulnerable to toxins. Several studies have revealed that the immune response associated with chronic digestive tract diseases can initiate brain inflammation and the death of dopaminergic neurons. Systemic inflammation initiated by Helicobacter Pylori can thus prepare the brain for Parkinson’s disease. Also, L-dopa, a precursor of dopamine, is used to treat Parkinson’s. What is it, H. Pylori infection disrupts the small intestine wall, which is the primary site of absorption of L-dopa, preventing the use of L-dopa by the body. Recent studies have shown that Parkinson’s patients with H. he showed that pylori treatment can improve the bioavailability of L-dopa.
Alzheimer:
H in the cerebrospinal fluid of Alzheimer’s patients infected with Helicobacter Pylori. Elevated levels of the Pylori-specific IgG antibody, IL-8 and TNF have been found. This systemic inflammation may be involved in the development of Alzheimer’s. Also, H. Low stomach acid caused by pylori reduces vitamin B levels, which in turn leads to increased homocysteine. Homocysteine is an important risk factor for dementia. Persons with mild cognitive impairment in the brain of homocysteine-induced oxidative damage is defined, and this oxidative damage may be one of the earliest events in the onset and progression of Alzheimer’s disease suggests.
Guiain-barre syndrome:
A disease that occurs as a progressive motor weakness that usually begins in the legs and can be triggered by a bacterial or viral infection. In studies, the causative agents of diseases of the digestive tract were Campylobacter jejuni and H. Antigens found in Pylori bacteria have been found in the spinal fluids of people with Guillain-Barré syndrome.
Ischemic stroke:
The majority of ischemic strokes are a blockage of the vessels that supply the brain and heart. H. Pylori, on the other hand, activates platelets and affects coagulation. These aspects contribute to vascular occlusion. Also studies have shown that H. It has been shown that 6 months after the activation of Pylori infection, the levels of total cholesterol, low density lipoprotein-cholesterol, high C-reactive protein, fibrinogen and IL-8 in the blood increase. It is known that it increases homocysteine with it. All these values are important risk factors for stroke and other vascular diseases. It increases the risk of atherosclerosis, increases blood density, promotes the formation of blood clots and causes a systemic inflammation of blood vessels.
.
.
.
.
Turkey's world-renowned organ transplant specialist. Dr. Demirbaş has 104 international publications and 102 national publications.
Physician's Resume:
Born on August 7, 1963 in Çorum, Prof. Dr. Alper Demirbaş has been continuing his work as the President of MedicalPark Antalya Hospital Organ Transplantation Center since 2008.
Prof. who performed the first tissue incompatible kidney transplant in Turkey, the first blood type incompatible kidney transplant, the first kidney-pancreas transplant program and the first cadaveric donor and live donor liver transplant in Antalya. Dr. As of August 2016, Alper Demirbaş has performed 4900 kidney transplants, 500 liver transplants and 95 pancreas transplants.
In addition to being the chairman of 6 national congresses, he has also been an invited speaker at 12 international and 65 national scientific congresses. Dr. Alper Demirbaş was married and the father of 1 girl and 1 boy.
Awards:
Eczacibasi Medical Award of 2002, Akdeniz University Service Award of 2005, Izder Medical Man of the Year Award of 2006, BÖHAK Medical Man of the Year Award of 2007, Sabah Mediterranean Newspaper Scientist of the Year Award of 2007, ANTIKAD Scientist of the Year Award of 2009, Social Ethics Association Award of 2010, Işık University Medical Man of the Year Award of 2015, VTV Antalya's Brand Value Award of 2015.
Certificates:
Doctor of Medicine Degree Hacettepe University Faculty of Medicine Ankara, General Surgeon Ministry of Health Turkey EKFMG (0-477-343-8), University of Miami School of Medicine Member of Multiple Organ Transplant, ASTS Multiorgan Transplant Scholarship. Lecturer at Kyoto University. Lecturer at University of Essen, Research assistant at the University of Cambridge .
Professional Members:
American Society of Transplant Surgeons, American Transplantation Society Nominated, Middle East and Southern Africa Council Transplantation Society 2007, International Liver Transplantation Association, Turkish Transplantation Association, Turkish Society of Surgery, Turkish Hepatobiliary Surgery Association.
Disclaimer:
Our website contents consist of articles approved by our Web and Medical Editorial Board with the contributions of our physicians. Our contents are prepared only for informational purposes for public benefit. Be sure to consult your doctor for diagnosis and treatment.