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KIDNEY CANCER! WHAT ARE THE SYMPTOMS?
Kidney cancer is a tumor that has increased in incidence all over the world and in our country and accounts for about 3 percent of adult cancer cases. It is observed 2 times more often in men than in women and usually occurs between ages of 40 and 70. Turkey Medicals member and Urologist Assoc. Dr. told you about what is curious about kidney cancer and its treatment for you.
There are about 400 thousand kidney cancer patients all over the world, and this number is expected to exceed 650 thousand in 2040. It is estimated that the number of kidney cancer cases in our country, which is about 5 thousand, will be 7800 in 2040.
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WHAT ARE THE RISK FACTORS?
Some risk factors associated with the development of kidney cancer have been identified. These are smoking, obesity, high blood pressure, exposure to toxic chemical agents, and genetic causes that double the risk of developing the disease. Carcinogenic toxic substances contained in cigarette smoke are filtered through the kidneys, which act as a filter in the body after they enter the blood from the lungs. These toxic substances damage kidney cells and increase the risk of developing kidney cancer.
People with chronic kidney failure, patients on dialysis, and people who have had a kidney transplant have an increased risk of developing a kidney tumor. In addition, having a relative with kidney cancer in the family increases the risk of developing kidney cancer. It is known that the risk of developing kidney cancer is high in diseases with gene mutations, such as von Hippel-Lindau and tuberous sclerosis.
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WHAT ARE THE SYMPTOMS?
In the vast majority of kidney cancer patients, the disease progresses insidiously without symptoms until later periods. But when it reaches the final stages and bounces to other organs, it causes complaints such as cough, bone pain, jaundice, weight loss. Most of the patients diagnosed at an early stage are detected by chance during radiological imaging methods performed for another reason. The classic symptoms of kidney cancer, such as blood coming from the urine, side pain, and mass coming to the hand, are only monitored in a small proportion of 10-15 percent of patients. Due to the fact that survival rates of more than 90 percent are achieved with early diagnosis, it is very important that people with a family history and risk factors do not disrupt routine urological checkups, especially.
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HOW IS THE DIAGNOSIS MADE?
The patient’s history (anamnesis) and physical examination are the first steps towards reaching a diagnosis. During the examination, it is investigated whether there is stiffness or a mass coming to the hand, especially in the side areas of the abdomen where the kidneys are located. The patient’s complaints, history, and the doctor’s initial evaluation findings are very important to determine the research that will be done later. By looking at blood biochemistry and urine analysis as laboratory tests, information is obtained about whether there is bleeding in the urine and the function of the kidneys. Kidney cancer is usually diagnosed by imaging methods. For this purpose, radiological examinations such as Ultrasound (US), Tomography (CT), MRI examination and PET are used.
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HOW IS THE TREATMENT PERFORMED?
The main method of treating kidney tumors is surgery. Depending on the size and location of the tumor, operations are performed to completely remove the tumor kidney (radical nephrectomy) or to remove only the tumor part (partial nephrectomy). Currently, these operations can also be performed by laparoscopic or robotic surgery in appropriate cases. For suitable patients with a small tumor, ablative treatments (microwave thermal ablation, radiofrequency ablation, cryotherapy) can be performed, in which only the part with the tumor is burned, protecting the kidney that we call. In this way, the tumor part can be destroyed without damaging the kidney. Again, in patients with a small tumor, when the risk of surgical intervention outweighs the oncological benefits that treatment will bring, close monitoring with active monitoring can be performed.
If the disease has spread to other organs, surgery and targeted therapies received quite a good response in addition to drugs that stimulate the immune system (immunotherapy) it is recommended to use. In recent years, it has been that very successful results have been obtained in these chemotherapy-resistant tumors with the combined use of immunotherapy and targeted agents.
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