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IS CANCER HEREDITARY?
When talking about cancer, it is impossible to interpret the topic without ‘genetics’ because the cause of cancer is mutation.
In the minds of most people whose relatives died due to cancer, the question “will I have cancer?” the question takes place. Studies on this issue show that 90-95% of many cancers, including lung, prostate, bowel and skin cancer, are not inherited in people except in a few cases. When talking about cancer, it is impossible to interpret the topic without ‘genetics’ because the cause of cancer is mutation.
Turkey Medicals – but from the genetics of cancer, we mean that as a result of mutations that are mostly (90-95%) formed by environmental conditions and/or nutrition and remain beyond repair, normal cells turn into abnormal cells, and these abnormal cells divide and multiply uncontrollably.
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In other words, in this case, the person does not have these mutations/s when he is born, and these mutations are not passed on to his children. By the word genetics, transmission to family members is not meant.
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The place of cancer in society
Currently, cancer is the cause of two out of every ten deaths in America. This rate is also high in our country. For example, if 10 of your relatives have died, it is not familial that the cause of death of 2 or 3 of them is cancer, but an expected result. If all of these people who have died have smoked in their health, the fact that more than 3 out of 10 people have died due to cancer is again a statistically expected result.
Studies conducted with identical twins also provide similar results, if one of the twins has cancer, the rate of cancer of the other twin was not found to be different from other individuals in society.
Very few people with cancer have underlying familial factors. In this rare inherited group, cancer-sensitive genes are passed on to other members of the family. These genes do not directly cause cancer because a number of mutations are required for the development of cancer. This is also the reason why cancer is more common in adults than in children, because the time necessary for the accumulation of errors is provided. People who carry such genes are more susceptible to environmental factors that cause cancer compared to people who do not carry them.
What are the genes that are known to be associated with cancer?
Genes that are sensitive to certain types of cancer have been identified, and it has been found that most of these damaged genes cause cancer in certain organs. For example, BRCA1 and BRCA2 genes are involved in breast, ovarian and prostate cancers, APC, KRAS, MSH2 and MLH1 genes are involved in bowel cancer, VHL gene is involved in von Hippel-Lindau syndrome, and STK11 gene is involved in Peutz-Jeggers syndrome. TP53 and RB1, on the other hand, are associated with many non-familial and spontaneously developing cancers.
In people who carry mutant (abnormal) copies of these genes, these types of cancer are observed more often than in society. A person’s lifestyle (nutrition, smoking, alcohol consumption, work environment) is effective in combination with these genes in terms of laying the foundation for cancer. The absence of mutations in genetic tests does not mean that there is no risk and there is no definite cure for cancer, only that the possibility of developing a hereditary form of cancer is largely eliminated. The risk of developing non-hereditary cancer remains the same as in other individuals in society.
Can we avoid mutations and cancer?
In fact, mutation is not a very unnatural condition for a cell, we all experience mutations every day. These mutations/s occurring in the DNA are detected by the cell and are also repaired by the products of repair genes.
In research, it has been found that when a healthy cell is fused with a cancer cell, the cells that divide and multiply from this new cell that are formed are not cancer cells, but normal cells. This is because proteins, which are products of repair genes in a healthy cell, repair disorders (mutations) in a cancer cell. It is possible to prevent cancer by keeping our genes intact by taking care of our nutrition and lifestyle.
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Turkey's world-renowned organ transplant specialist. Dr. Demirbaş has 104 international publications and 102 national publications.
Physician's Resume:
Born on August 7, 1963 in Çorum, Prof. Dr. Alper Demirbaş has been continuing his work as the President of MedicalPark Antalya Hospital Organ Transplantation Center since 2008.
Prof. who performed the first tissue incompatible kidney transplant in Turkey, the first blood type incompatible kidney transplant, the first kidney-pancreas transplant program and the first cadaveric donor and live donor liver transplant in Antalya. Dr. As of August 2016, Alper Demirbaş has performed 4900 kidney transplants, 500 liver transplants and 95 pancreas transplants.
In addition to being the chairman of 6 national congresses, he has also been an invited speaker at 12 international and 65 national scientific congresses. Dr. Alper Demirbaş was married and the father of 1 girl and 1 boy.
Awards:
Eczacibasi Medical Award of 2002, Akdeniz University Service Award of 2005, Izder Medical Man of the Year Award of 2006, BÖHAK Medical Man of the Year Award of 2007, Sabah Mediterranean Newspaper Scientist of the Year Award of 2007, ANTIKAD Scientist of the Year Award of 2009, Social Ethics Association Award of 2010, Işık University Medical Man of the Year Award of 2015, VTV Antalya's Brand Value Award of 2015.
Certificates:
Doctor of Medicine Degree Hacettepe University Faculty of Medicine Ankara, General Surgeon Ministry of Health Turkey EKFMG (0-477-343-8), University of Miami School of Medicine Member of Multiple Organ Transplant, ASTS Multiorgan Transplant Scholarship. Lecturer at Kyoto University. Lecturer at University of Essen, Research assistant at the University of Cambridge .
Professional Members:
American Society of Transplant Surgeons, American Transplantation Society Nominated, Middle East and Southern Africa Council Transplantation Society 2007, International Liver Transplantation Association, Turkish Transplantation Association, Turkish Society of Surgery, Turkish Hepatobiliary Surgery Association.
Disclaimer:
Our website contents consist of articles approved by our Web and Medical Editorial Board with the contributions of our physicians. Our contents are prepared only for informational purposes for public benefit. Be sure to consult your doctor for diagnosis and treatment.